The Association of Clinical Pathologists: 92nd general meeting
نویسنده
چکیده
Twenty-eight isolates of Enterobacteriaceae were obtained from inpatients and outpatients with significant urinary tract infections. The effect of co-trimoxazole or its separate components was then determined upon shake cultures of these organisms in urine obtained from healthy subjects. Co-trimoxazole did not have a significant bactericidal effect upon any of the organisms. Trimethoprim alone had a bactericidal effect upon about one quarter of the organisms. Sulphamethoxazole thus appears to antagonize the bactericidal effect of trimethoprim in urine. Volunteers were given therapeutic doses of either co-trimoxazole or equivalent amounts of its individual components. Urine from these individuals was found to have a similar effect upon the test organisms as synthetic mixtures of these various antimicrobials in normal urine. There appears therefore to be a good case for further clinical trials to compare trimethoprim and co-trimoxazole in the treatment of urinary tract infections.
منابع مشابه
Wessex Branch of the Association of Clinical Pathologists Winter Meeting 1992
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s of the Association of Clinical Pathologists
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